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THE TORONTO CENTRE FOR PHENOGENOMICS
MOUSE IMAGING CENTRE |
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Contact UsLynda Cockroft Primary InvestigatorsR. Mark Henkelman, Ph.D., Ph.D. is a University Professor of the University of Toronto and holder of a Canada Research Chair and a Fellow of the Royal Society of Canada. In 2010, he was awarded the Killam Prize in Health Science by the Canada Council. He is the director of the Mouse Imaging Centre (MICe) and a Senior Scientist at the Hospital for Sick Children. At MICe, his research focus is on providing a comprehensive assessment of mice using various imaging modalities as a critical resource for genomic research. He is a co-author on more than 340 publications and over 620 abstracts. He is regularly invited worldwide to speak about mouse imaging. As an antidote to these academic pursuits, he likes to go canoeing and kayaking whenever possible. Jason P. Lerch, Ph.D. is a Scientist at the Hospital for Sick Children and an Assistant Professor in medical biophysics at the University of Toronto. Jason joined MICe in August 2005 as a postdoctoral fellow to work with Dr. Mark Henkelman and Dr. John Sled. Prior to MICe, he completed his Ph.D. in 2005 in the department of neurology and neurosurgery at McGill University. He received his B.A. in 1999 in anthropology and social studies of medicine from McGill University. His Ph.D. research was on in-vivo measurements of cortical thickness from MRI. While at MICe, his research focus is on detecting neuroanatomical changes due to behavioural and genetic manipulations in tightly controlled mouse models and to relate these findings to sadly not so well controlled human subjects. Brian J. Nieman, Ph.D. is a Scientist at the Hospital for Sick Children and the Mouse Imaging Centre and a New Investigator with the Ontario Institute for Cancer Research. Brian completed his B.Sc. in 2001 from the department of physics at the University of Waterloo. He received his Ph.D. in 2006 from the department of medical biophysics at the University of Toronto. In his Ph.D. work, he developed tools for MR imaging and neuroanatomical screening of mice under the supervision of Dr. R. Mark Henkelman. He subsequently continued his studies with a postdoctoral fellowship at the Skirball Institute of the New York University School of Medicine with Dr. Daniel H. Turnbull. While in New York, he developed methods for MR imaging of mice in early developmental stages and applied cellular imaging methods to characterize neural progenitor cell migration dynamics. Brian's current research interests include neuroanatomical development, cellular imaging, tumorigenesis, and cancer treatment. John G. Sled, Ph.D. is an Associate Professor in the department of medical biophysics at the University of Toronto and a Senior Scientist at the Hospital for Sick Children. His current research interests include the genetic and environmental determinants of vascular patterning and the development of quantitative imaging techniques for assessing morphology and function. John received an M.Eng. in 1997 from the department of biomedical engineering at McGill University for his work on the causes and remedies of intensity non-uniformity artifacts in MRI. He received his Ph.D. from the department of electrical engineering at McGill University in 2001 for his work on quantitative magnetization transfer imaging. From 2001-2003, he was a postdoctoral fellow in Imaging Research at Sunnybrook Health Sciences Centre with Dr. Mark Henkelman. During that period, he investigated the use of micro-computed tomography for characterizing the microvasculature of whole organs. Mouse Imaging Centre PersonnelRylan Allemang-Grand is a M.Sc. student in the department of medical biophysics at the University of Toronto and he joined MICe in 2011 to work with Dr. Jason Lerch. Rylan received an Honours B.Sc. with a specialization in psychology from the University of Ottawa in 2011. His research is currently focused on imaging cognitive reserve. Gregory Anderson is a Ph.D. student at the Mouse Imaging Centre. He joined MICe in February 2008 and is working with Dr. Mark Henkelman on the vascular development in the mouse embryo. Greg received his B.Sc. (Honours) in the biochemistry co-op program at the University of Waterloo in 2004 and his M.Sc. in medical biophysics at the University of Toronto in 2008. Jonathan Bishop, Ph.D. has been a senior research engineer at the Mouse Imaging Centre since 2002, responsible for supporting the spectrometer hardware and software. His research focuses on methods for cardiac imaging of multiple mice. Prior to joining MICe, Jonathan worked at Colorado Medtech for two years. Jonathan received his Ph.D. from the department of medical biophysics at the University of Toronto in 1997. Lindsay Cahill, Ph.D. joined the Mouse Imaging Centre as a postdoctoral fellow in June 2009 and then as a research associate starting in 2012. Her current research focuses on mouse models of neurodegenerative disease using MR and micro-CT, quantitative MR methods for spine imaging, understanding how the cerebral vascular networks reorganize with exercise and studying the vascular response of the fetal brain during hypoxia. She received her Ph.D. in chemistry from McMaster University under the supervision of Dr. Gillian Goward. From 2008-09, she was a postdoctoral fellow in the department of physics with Dr. Mark Smith at the University of Warwick, UK. Marc Carias is a M.Sc. student at the University of Toronto in medical biophysics. He joined MICe in July 2010 and is working with Dr. Brian Nieman. Marc holds a bachelor of medical science with an honours specialization in medical biophysics from the University of Western Ontario in London, Ontario. In London, he completed his third and fourth year undergraduate thesis at the Robarts Imaging Laboratories. There he focused on using low-field magnetic resonance (MR) imaging to image the lung, in particular radio frequency coil design. Marc is involved with MR hardware at MICe, here he will designed and implemented the next generation of high-resolution, high-throughput MR imaging for research applications. Lynda Cockroft has been the administrative assistant at the Mouse Imaging Centre since April 2003. She is the primary assistant for the scientists at MICe (R. Mark Henkelman, John G. Sled, Jason P. Lerch and Brian J. Nieman). Prior to joining MICe, she was a research coordinator in Imaging Research at Sunnybrook Health Sciences Centre with Dr. Mark Henkelman and Dr. Stuart Foster. She has been with Dr. Henkelman since 1996. Her prior experience includes academic and research administrative responsibilities at Calvin Theological Seminary in Grand Rapids, Michigan from 1984-1989 and at Redeemer College-University in Ancaster, Ontario from 1989-1996. Lynda received her B.A. from the University of Waterloo in 1979 and a joint M.T.S.-M.S.W. from Wilfred Laurier University in 1989. Jun Dazai s a mechanical engineer at the Mouse Imaging Centre and graduated from the mechanical engineering program at the University of Toronto in 2001. His major research focus at MICe is to design and implement a multiple-mouse coil array that allows for rapid and reproducible loading of anaesthetized mice. Elizabeth de Guzman is a M.Sc. student at the University of Toronto in medical biophysics. She joined MICe in September 2011 after completing a B.A.Sc. in biomedical engineering at Simon Fraser University in Vancouver BC. Her research, under the supervision of Dr. Brian Nieman, focuses on neuroanatomical late effects resulting from pediatric brain irradiation. Jacob Ellegood , Ph.D. is a research associate at the Mouse Imaging Centre. Jacob joined MICe in January 2008. He received his Ph.D. in biomedical engineering from the University of Alberta in Edmonton. He received his B.Sc. in physics from the University of Lethbridge (Alberta) in 2002. The current focus of his research is Autism. Since Autism has a strong genetic basis, his research project will examine a number of genetically altered mouse models relevant to Autism, and use advanced magnetic resonance imaging (MRI) techniques to measure and compare volume and micro-structural changes in the brain related to the genetic modification. Miriam Friedel, Ph.D. joined MICe as a programmer/analyst in April 2011. She received her B.S. in physics from Brown University in 2000 and her Ph.D. in physics from the University of California, Santa Barbara in 2006. Her Ph.D. research was in the area of computational biophysics, using simplified models of proteins to understand how they fold and aggregate. Prior to joining MICe, Miriam worked as a management and IT consultant, doing both software development and business analysis. Her responsibilities include MR image registration and data analysis as part of various collaborations, as well as designing and writing software to help support the research at MICe. Jürgen Germann joined the Mouse Imaging Centre in 2009 and has a degree in psychology from the Albert-Ludwigs University in Freiburg, Germany, and a B.A. in psychology from Brock University in St. Catharines, Ontario. Jürgen's research is focused on studying how the brain changes its shape in response to learning and experience. Sahar Ghanavati is a Ph.D. student in the department of medical biophysics at the University of Toronto. She joined MICe in September 2010. Sahar completed her M.Sc. in 2010 at Queen's University, Kingston, ON and her B.Sc. in 2008 in electrical engineering at Sharif University of Technology, Iran. Her research focuses on imaging and analysis of cerebral vascular morphology using in-vivo MRA-TOF and contrast-enhanced ex-vivo micro-CT and utilizing machine learning algorithms. Colin Gram is a M.Sc. student at the University of Toronto in medical biophysics, and he joined MICe in 2012 to work with Dr. Brian Nieman. Colin received a B.Sc. in nanoscience from the University of Guelph in 2012. His research is currently focused on neurovascular and neuroanatomical response during development after irradiation. Christine Laliberté joined the Mouse Imaging Centre in April 2008 as a laboratory research project manager. Christine received her diploma in bio-chemistry in 1990 from College Ahuntsic in Montréal, Québec. From 1990-1996, she worked in two different laboratories as a research technologist at the McConnell Brain Imaging Centre at the Montreal Neurological Institute, McGill University. There, the research focused on the study of neurological conditions following cerebral stroke and the regulation of neurotransmitters involved in Parkinson's disease, both in rats. In 1996, she became a laboratory manager at the Brain Tumor Research Centre at Montreal Neurological Institute with Dr. David R. Kaplan. In 2002, she began working at the Hospital for Sick Children when Dr. Kaplan moved his laboratory to SickKids. With the Kaplan lab, the research focused on the investigation of motor and cognitive functional deficits that are associated with age- or Alzheimer's Disease-related neurodegeneration in addition to her management responsibilities. At MICe, her responsibilities include live and fixed imaging of the mouse brain at high resolution. Marcus Reynoso has been a grant accountant with the Hospital for Sick Children since August 2010 and joined the MICe team in August 2011. He is primarily responsible for financial reporting on government awarded infrastructure grants. Marcus attended Ryerson University where he majored in accounting and minored in psychology while concentrating on obtaining a Bachelor of Commerce degree. Prior to joining the Hospital for Sick Children and MICe, Marcus spent 2 years at CIBC Mellon as a fund accountant where he performed daily calculations of the Net Asset Value, yields, distributions and investment close prices on mutual funds. Jan Scholz, Ph.D. is a postdoctoral fellow at the Mouse Imaging Centre who joined in March 2011. Jan received a M.Sc. in cognitive neuroscience in 2006 at the Radboud Universiteit, The Netherlands, where he also was a founding editor of "Nijmegen CNS". He received his D.Phil. at the University of Oxford in 2010. While at Oxford, his work under Heidi Johansen-Berg included MR imaging of experience-related structural changes in humans and animals. At MICe, he will continue this work and explore cellular changes in response to experience and learning. Shoshana Spring is a laboratory research project coordinator at the Mouse Imaging Centre. She graduated in 2002 with an honours B.Sc. in immunology from the University of Toronto. She then received her M.Sc. degree in microbiology from the University of Guelph in 2005. Shoshana joined the Mouse Imaging Centre in June 2005 and is responsible for various collaborative and in-house projects involving optical projection tomography (OPT) and live and fixed magnetic resonance imaging (MRI). Patrick Steadman is a M.Sc. student at the University of Toronto in medical biophysics. He joined MICe first in 2010 as a research student developing a time course of neuroanatomical changes in the adult mouse brain associated with learning. Beginning in August 2011 as a graduate student with Dr. Lerch, Patrick's research focuses on the development of an image analysis pipeline to quantify anatomical features in the mouse cerebellum. This pipeline, along with mouse genetic models, will provide insight into neurodevelopmental diseases, such as ADHD and Autism. Patrick holds a B.Sc. Honours in medical and health physics from McMaster University in Hamilton, Ontario. Joe Steinman is a M.Sc. student in the department of medical biophysics at the University of Toronto. Joe joined MICe in September 2010 to work with Dr. John Sled. Joe received his B.Sc. in chemical physics from Trent University. His research focuses on using OPT to image the cerebrovascular adaptations in healthy and Alzheimer's mice. Dafna Sussman is a Ph.D. student at the department of medical biophysics at the University of Toronto. Dafna joined MICe in September 2009 and is working with Dr. Mark Henkelman. Dafna received her B.A.Sc. Honours in engineering science with a physics specialty from the University of Toronto in 2007 and her M.Sc. in biophysics and optics from the University of Waterloo in 2009. Her research focuses on the use of MR and OPT imaging to determine the relationship between maternal gestational nutrition and embryonic development. Matthijs van Eede joined the Mouse Imaging Centre as a programmer/analyst in January 2007 to work with Dr. John Sled and Dr. Jason Lerch. Matthijs received a B.A.Sc. in computer science in 2004 and his M.Sc. in computer science and engineering specializing in visualization in 2008 from the Eindhoven University of Technology in Eindhoven, The Netherlands. His responsibilities include assisting in the design and implementation of image processing algorithms, with the main focus on image registration, to aid in the automated analysis of MR images of mice. Dulcie Vousden is a M.Sc. student in the department of medical biophysics at the University of Toronto where she is working with Dr. Jason Lerch. She received her B.Sc. in physiology and cognitive science from the University of Toronto in 2011. Her research is focused on the relationship between structural and cellular brain changes following learning. Michael Wong is a Ph.D. student at the University of Toronto in medical biophysics. He joined MICe in June 2007 and is working with Dr. Mark Henkelman. Michael received his B.Sc. Honours in medical physics at the University of Western Ontario in 2007. He reclassified into the Ph.D. program in April 2009. His research focus is developing high-throughput imaging and automated phenotyping of mouse embryos to compare the capability MRI, OPT and Micro-CT in finding anatomical abnormalities in mutant embryos. Lisa Yu is research technologist at the Mouse Imaging Centre working with the Micro-CT scanner. She joined MICe in February 2004. Lisa received her MD in 1983 from the Medical School of Shihezi, China. Prior to MICe, Lisa was a research technologist in Dr. Henkelman's lab in Imaging Research at Sunnybrook Health Sciences Centre. Xiaoli Zhang is a Ph.D. student at the University of Toronto in medical biophysics. Xiaoli received a B.Eng. and a M.Eng. in engineering physics from Tsinghua University, Beijing, China. He completed a M.Sc. in medical physics and applied radiation sciences from McMaster University in Hamilton, Ontario in 2006. Xiaoli joined MICe in October 2006 to work with Dr. Mark Henkelman. His research focuses on the relationship between hemodynamic wall shear (using phase contrast MRI, Doppler ultrasound, micro-CT and Computational Fluid Dynamics) and atherosclerotic plaque (with Optical Projection Tomography) in the aorta of aortic regurgitation mice. Yuqing Zhou, Ph.D. is a research associate at the Mouse Imaging Centre. He joined MICe in September 2002 as a postdoctoral fellow working with Dr. Mark Henkelman at MICe and Dr. Stuart Foster at Imaging Research, Sunnybrook Health Sciences Centre. The major focus of his research is the development of high frequency ultrasound imaging and new applications for ultrasound biomicroscopy in biological research. His specific research projects focus on cardiovascular physiology using various micro-imaging technologies in genetic mouse models of human disease such as atherosclerosis and the molecular imaging. Yuqing received his Ph.D. from the faculty of medicine at the University of Bergen, Norway in 1996. 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© 2004 Toronto Centre for Phenogenomics |
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