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Mouse Imaging Centre
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Jordan Heckbert
Mouse Imaging Centre
The Hospital for Sick Children
25 Orde Street
Toronto, Ontario M5T 3H7
Tel: 416-813-7654 ext 305492
Fax: 647-837-5832
Email: jordan.heckbert@sickkids.ca

Principal Investigators

John G. Sled, Ph.D., M.Eng. is a Senior Scientist at the Hospital for Sick Children, a Professor and vice-Chair in the department of Medical Biophysics at the University of Toronto, holds the Tier 1 Canada Research Chair in Biomedical Imaging, and is the director of the Mouse Imaging Centre (MICe). His research program spans multiple disciplines including medical imaging technology development, neuroscience, and obstetrics. John received an M.Eng. in 1997 from the department of Biomedical Engineering at McGill University for his work on the causes and remedies of intensity non-uniformity artifacts in MRI. He received his Ph.D. from the department of Electrical Engineering at McGill University in 2001 for his work on quantitative magnetization transfer imaging. From 2001-2003, he was a Postdoctoral Fellow in Imaging Research at Sunnybrook Health Sciences Centre with Dr. Mark Henkelman.

Brian J. Nieman, Ph.D. is a Senior Scientist at the Hospital for Sick Children and the Mouse Imaging Centre and a Level 2 Investigator with the Ontario Institute for Cancer Research. Brian completed his B.Sc. in 2001 from the department of Physics at the University of Waterloo. He received his Ph.D. in 2006 from the department of Medical Biophysics at the University of Toronto. In his Ph.D. work, he developed tools for MR imaging and neuroanatomical screening of mice under the supervision of Dr. R. Mark Henkelman. He subsequently continued his studies with a postdoctoral fellowship at the Skirball Institute of the New York University School of Medicine with Dr. Daniel H. Turnbull. While in New York, he developed methods for MR imaging of mice in early developmental stages and applied cellular imaging methods to characterize neural progenitor cell migration dynamics. Brian's current research interests include brain development, cancer treatment and cellular imaging.

Jason P. Lerch, Ph.D. is a Adjunt Scientist at the Hospital for Sick Children and a Professor of Neuroscience at the University of Oxford. Jason joined MICe in August 2005 as a Postdoctoral Fellow to work with Dr. Mark Henkelman and Dr. John Sled. Prior to MICe, he completed his Ph.D. in 2005 in the department of Neurology and Neurosurgery at McGill University. He received his B.A. in 1999 in Anthropology and Social Studies of Medicine from McGill University. His Ph.D. research was on in-vivo measurements of cortical thickness from MRI. While at MICe, his research focus is on detecting neuroanatomical changes due to behavioural and genetic manipulations in tightly controlled mouse models and to relate these findings to sadly not so well controlled human subjects.

R. Mark Henkelman, Ph.D. is a University Professor of the University of Toronto and holder of a Canada Research Chair and a Fellow of the Royal Society of Canada. In 2010, he was awarded the Killam Prize in Health Science by the Canada Council. He is the founding and former director of the Mouse Imaging Centre (MICe) and an Emeritus Scientist at the Hospital for Sick Children. At MICe, his research focus is on providing a comprehensive assessment of mice using various imaging modalities as a critical resource for genomic research. He is a co-author on more than 350 publications and over 620 abstracts. He is regularly invited worldwide to speak about mouse imaging. As an antidote to these academic pursuits, he likes to go canoeing and kayaking whenever possible.


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